[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …
NMDA and AMPA receptors dysregulation in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …
Dendritic spines: the locus of structural and functional plasticity
The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …
changed dramatically the rate of progress towards the understanding of the complex …
Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies
C Finsterwald, CM Alberini - Neurobiology of learning and memory, 2014 - Elsevier
A proper response against stressors is critical for survival. In mammals, the stress response
is primarily mediated by secretion of glucocorticoids via the hypothalamic–pituitary …
is primarily mediated by secretion of glucocorticoids via the hypothalamic–pituitary …
AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
Beta amyloid (Aβ), a peptide generated from the amyloid precursor protein (APP) by
neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent …
neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent …
[HTML][HTML] Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Q Zhou, KJ Homma, M Poo - Neuron, 2004 - cell.com
Activity-induced modification of neuronal connections is essential for the development of the
nervous system and may also underlie learning and memory functions of mature brain …
nervous system and may also underlie learning and memory functions of mature brain …
[HTML][HTML] Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach
The precise subunit composition of synaptic ionotropic receptors in the brain is poorly
understood. This information is of particular importance with regard to AMPA-type glutamate …
understood. This information is of particular importance with regard to AMPA-type glutamate …
Nutritional modulation of cognitive function and mental health
The important role of diet in cardiometabolic health is generally well recognised; for mental
health, it is not so well understood. However, lifestyle risk factors for poor physical health are …
health, it is not so well understood. However, lifestyle risk factors for poor physical health are …
AMPA receptor trafficking at excitatory synapses
DS Bredt, RA Nicoll - Neuron, 2003 - cell.com
Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …
The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …