Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement
dysregulation occurring in the fluid phase and in the glomerular microenvironment, which …

The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

Monoclonal gammopathy of renal significance (MGRS) regroups all renal disorders caused
by a monoclonal immunoglobulin (MIg) secreted by a nonmalignant B-cell clone. By …

The complement cascade, traditionally considered an effector arm of innate immunity
required for host defense against pathogens, is now recognized as a crucial pathogenic …

The complement system is increasingly recognized as important in the pathogenesis of
tissue injury in vivo following immune, ischemic, or infectious insults. Within the complement …

Objective To describe the clinicopathological features, complement abnormalities, triggers,
treatment, and outcomes of C3 glomerulopathy. Patients and Methods A total of 114 patients …

Recurrent glomerulonephritis (GN) is an important cause of kidney allograft failure,
particularly in younger recipients. Approximately 15% of death-censored graft failures are …

Monoclonal immunoglobulins (MIg) may play a causal role in C3 glomerulopathy (C3G) by
impairing regulation of the alternative pathway of complement. Ninety-five patients with C3G …

Abstract C3 glomerulonephritis (C3GN) results from abnormalities in the alternative pathway
of complement, and it is characterized by deposition of C3 with absent or scant Ig deposition …