Despite the surge of microbial genome data, experimental testing is important to confirm
inferences about the cell biology, ecological roles and evolution of microorganisms. As the …

Metagenomics and 16S pyrosequencing have enabled the study of ecosystem structure and
dynamics to great depth and accuracy. Co-occurrence and correlation patterns found in …

Antibiotic resistance is spreading faster than the introduction of new compounds into clinical
practice, causing a public health crisis. Most antibiotics were produced by screening soil …

We are experiencing an antimicrobial resistance (AMR) crisis, brought on by the drying up of
the antibiotic discovery pipeline and the resulting unchecked spread of resistant pathogens …

The gut microbiota has an important role in the maintenance of human health and in disease
pathogenesis. This importance was realized through the advent of omics technologies and …

The spread of resistant bacteria, leading to untreatable infections, is a major public health
threat but the pace of antibiotic discovery to combat these pathogens has slowed down …

Global population growth poses a threat to food security in an era of increased ecosystem
degradation, climate change, soil erosion, and biodiversity loss. In this context, harnessing …

Microorganisms produce a wealth of structurally diverse specialized metabolites with a
remarkable range of biological activities and a wide variety of applications in medicine and …

Dormancy is a bet-hedging strategy used by a wide range of taxa, including
microorganisms. It refers to an organism's ability to enter a reversible state of low metabolic …

The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …