Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …

The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Obesity is a global epidemic, placing socioeconomic strain on public healthcare systems,
especially within the so-called Western countries, such as Australia, United States, United …

A fundamental question of physiology is how gut-brain signaling stimulates appetite. While
many studies have emphasized the importance of vagal afferents to the brain in inducing …

Cannabinoids—the active components of Cannabis sativa and their derivatives—exert
palliative effects in cancer patients by preventing nausea, vomiting and pain and by …

The cannabinoid receptor type 1 (CB1) and its endogenous ligands, the endocannabinoids,
are involved in the regulation of food intake. Here we show that the lack of CB1 in mice with …

Endogenous cannabinoids acting at CB1 receptors stimulate appetite, and CB1 antagonists
show promise in the treatment of obesity. CB1–/–mice are resistant to diet-induced obesity …

During the last few years, the endocannabinoid system has emerged as a highly relevant
topic in the scientific community. Many different regulatory actions have been attributed to …