Evidence suggests a role for low-grade inflammation and oxidative stress in the
pathophysiology of bipolar disorder. We conducted a systematic review and meta-analysis …

Decades of research have identified genetic and environmental factors involved in age-
related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders …

Importance Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular
mechanism driving the severely increased morbidity and mortality from somatic causes in …

Objective Oxidative DNA damage has been associated with the pathophysiology of bipolar
disorder (BD) as one of the common pathways between increased medical comorbidity and …

Background: Increasing evidence suggests that the presence of oxidative stress and
disorders of the antioxidant defense system are involved in a wide range of neuropsychiatric …

Background Low-grade inflammation and oxidative stress have been implicated as potential
pathophysiological processes in bipolar disorder, but the underlying mechanism is …

Excessive oxidative stress-generated nucleoside damage seems to play a key role in
bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and …

Introduction Accumulating data support the association between increased inflammation
and bipolar disorder (BD), and preliminary data suggest that augmentation with low-dose …

Chromatographic techniques have found wide application in the quantitative analysis of
modified deoxynucleosides in DNA and biological fluids, which is also reflected in clinical …

Previous evidence suggests elevated levels of oxidatively-induced DNA damage,
particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8 …