Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

The function of antibodies (Abs) involves specific binding to antigens (Ags) and activation of
other components of the immune system to fight pathogens. The six hypervariable loops …

Physical interactions between proteins are essential for most biological processes
governing life. However, the molecular determinants of such interactions have been …

We discuss basic physical–chemical principles underlying the formation of stable
macromolecular complexes, which in many cases are likely to be the biological units …

This is a sequel to the previous Perspective “The CH–π hydrogen bond in chemistry.
Conformation, supramolecules, optical resolution and interactions involving carbohydrates” …

Transient interactions, which involve protein interactions that are formed and broken easily,
are important in many aspects of cellular function. Here we describe structural and functional …

Antibody design is valuable for therapeutic usage and biological research. Existing deep-
learning-based methods encounter several key issues: 1) incomplete context for …

Abstract The Fast Fourier Transform (FFT) correlation approach to protein–protein docking
can evaluate the energies of billions of docked conformations on a grid if the energy is …

Abstract ClusPro (http://nrc. bu. edu/cluster) represents the first fully automated, web-based
program for the computational docking of protein structures. Users may upload the …

Motivation: Predicting protein interactions is one of the most challenging problems in
functional genomics. Given two proteins known to interact, current docking methods …