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Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …
considered two of the most important causes of death. Experimental and clinical evidence …
AMPK, metabolism, and vascular function
Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …
activated during energy stress that plays a key role in maintaining energy homeostasis. This …
The relevant targets of anti-oxidative stress: a review
J Qi, F Dong - Journal of drug targeting, 2021 - Taylor & Francis
Previous studies have found that oxidative stress is the negative reaction of the imbalance
between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and …
between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and …
Experimental animal models of coronary microvascular dysfunction
Coronary microvascular dysfunction (CMD) is commonly present in patients with metabolic
derangements and is increasingly recognized as an important contributor to myocardial …
derangements and is increasingly recognized as an important contributor to myocardial …
[HTML][HTML] International union of basic and clinical pharmacology. CIX. Differences and similarities between human and rodent prostaglandin E2 receptors (EP1–4) and …
Prostaglandins are derived from arachidonic acid metabolism through cyclooxygenase
activities. Among prostaglandins (PGs), prostacyclin (PGI 2) and PGE 2 are strongly involved …
activities. Among prostaglandins (PGs), prostacyclin (PGI 2) and PGE 2 are strongly involved …
Protective role of perivascular adipose tissue in the cardiovascular system
Y Tong, Z Zuo, X Li, M Li, Z Wang, X Guo… - Frontiers in …, 2023 - frontiersin.org
This review provides an overview of the key role played by perivascular adipose tissue
(PVAT) in the protection of cardiovascular health. PVAT is a specific type of adipose tissue …
(PVAT) in the protection of cardiovascular health. PVAT is a specific type of adipose tissue …
The deleterious role of the prostaglandin E2 EP3 receptor in angiotensin II hypertension
TD Bryson, TS Pandrangi, SZ Khan… - American Journal …, 2020 - journals.physiology.org
Angiotensin II (ANG II) plays a key role in regulating blood pressure and inflammation.
Prostaglandin E2 (PGE2) signals through four different G protein-coupled receptors, eliciting …
Prostaglandin E2 (PGE2) signals through four different G protein-coupled receptors, eliciting …
[HTML][HTML] Onion and apple functional ingredients intake improves antioxidant and inflammatory status and vascular injury in obese Zucker rats
C Balderas, J Angulo, A Sevilleja-Ortiz, C Peiró… - Antioxidants, 2022 - mdpi.com
The objective of this study was to investigate the effects of onion and apple functional
ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard …
ingredients in homozygous (fa/fa) obese Zucker rats. Rodents were fed three diets: standard …
CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries
Reactive oxygen species (ROS) like hydrogen peroxide (H 2 O 2) are involved in the in
endothelium-derived hyperpolarization (EDH)-type relaxant responses of coronary and …
endothelium-derived hyperpolarization (EDH)-type relaxant responses of coronary and …
Moderate-intensity exercise improves mesenteric arterial function in male UC Davis type-2 diabetes mellitus (UCD-T2DM) rats: a shift in the relative importance of …
The beneficial cardiovascular effects of exercise are well documented, however the
mechanisms by which exercise improves vascular function in diabetes are not fully …
mechanisms by which exercise improves vascular function in diabetes are not fully …