Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …

Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market …

Abstract Background & Aims Preclinical identification of compounds at risk of causing drug
induced liver injury (DILI) remains a significant challenge in drug development, highlighting …

Macroalgae are valuable and structurally diverse sources of bioactive compounds among
marine resources. The cell walls of macroalgae are rich in polysaccharides which exhibit a …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

The limitations of traditional two-dimensional (2D) cultures and animal testing, when it
comes to precisely foreseeing the toxicity and clinical effectiveness of potential drug …

Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

Recent research has shown that the maintenance of relevant liver functions ex vivo requires
models in which the cells exhibit an in vivo‐like phenotype, often achieved by reconstitution …