The ECM: to scaffold, or not to scaffold, that is the question
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …
Novel drug delivery systems and disease models for pulmonary fibrosis
R Li, Y Jia, X Kong, Y Nie, Y Deng, Y Liu - Journal of Controlled Release, 2022 - Elsevier
Pulmonary fibrosis (PF) is a serious and progressive lung disease which is possibly life-
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
threatening. It causes lung scarring and affects lung functions including epithelial cell injury …
Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies
B Selvarajah, M Platé, RC Chambers - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis is the concluding pathological outcome and major cause of morbidity and mortality
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …
3D organ-on-a-chip: The convergence of microphysiological systems and organoids
Medicine today faces the combined challenge of an increasing number of untreatable
diseases and fewer drugs reaching the clinic. While pharmaceutical companies have …
diseases and fewer drugs reaching the clinic. While pharmaceutical companies have …
Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research
Chronic lung diseases result from alteration and/or destruction of lung tissue, inevitably
causing decreased breathing capacity and quality of life for patients. While animal models …
causing decreased breathing capacity and quality of life for patients. While animal models …
Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications
Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …
closer mimicry of human physiology compared to traditional two-dimensional cell culture …
Lung organoids—the ultimate tool to dissect pulmonary diseases?
V Bosáková, M De Zuani, L Sládková… - Frontiers in Cell and …, 2022 - frontiersin.org
Organoids are complex multicellular three-dimensional (3D) in vitro models that are
designed to allow accurate studies of the molecular processes and pathologies of human …
designed to allow accurate studies of the molecular processes and pathologies of human …
Biomechanical force and cellular stiffness in lung fibrosis
Lung fibrosis is characterized by the continuous accumulation of extracellular matrix (ECM)
proteins produced by apoptosis-resistant (myo) fibroblasts. Lung epithelial injury promotes …
proteins produced by apoptosis-resistant (myo) fibroblasts. Lung epithelial injury promotes …
[HTML][HTML] On the path to predicting immune responses in the lung: modeling the pulmonary innate immune system at the air-liquid interface (ALI)
Chronic respiratory diseases and infections are among the largest contributors to death
globally, many of which still have no cure, including chronic obstructive pulmonary disorder …
globally, many of which still have no cure, including chronic obstructive pulmonary disorder …
Development of lung tissue models and their applications
N Petpiroon, W Netkueakul, K Sukrak, C Wang, Y Liang… - Life Sciences, 2023 - Elsevier
The lungs are important organs that play a critical role in the development of specific
diseases, as well as responding to the effects of drugs, chemicals, and environmental …
diseases, as well as responding to the effects of drugs, chemicals, and environmental …