Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …

Materials patterned with high‐aspect‐ratio nanostructures have features on similar length
scales to cellular components. These surfaces are an extreme topography on the cellular …

Electroporation (EP) is a commonly used strategy to increase cell permeability for
intracellular cargo delivery or irreversible cell membrane disruption using electric fields. In …

Intracellular delivery of advanced therapeutics, including biologicals and supramolecular
agents, is complex because of the natural biological barriers that have evolved to protect the …

Chimeric antigen receptor (CAR)‐T cell therapy has emerged as a promising cell‐based
immunotherapy approach for treating blood disorders and cancers, but genetically …

Innate cell function can be artificially engineered and reprogrammed by introducing
biomolecules, such as DNAs, RNAs, plasmid DNAs, proteins, or nanomaterials, into the …

Localized surface plasmon resonance (LSPR) excited by an incident light can normally
produce strong surface‐enhanced Raman scattering (SERS) at the nanogaps among …

Resistive-pulse sensing is a technique widely used to detect single nanoscopic entities such
as nanoparticles and large molecules that can block the ion current flow through a nanopore …

The plasma membrane (PM) is often described as a wall, a physical barrier separating the
cell cytoplasm from the extracellular matrix (ECM). Yet, this wall is a highly dynamic structure …

Conspectus In human cells, intracellular access and therapeutic cargo transport, including
gene-editing tools (eg, CRISPR–Cas9 and transposons), nucleic acids (eg, DNA, mRNA …