Biochemical and genetic characterization of D-type cyclins, their cyclin D–dependent
kinases (CDK4 and CDK6), and the polypeptide CDK4/6 inhibitor p16INK4 over two …

Cancer proliferation and progression involves altered metabolic pathways as a result of
continuous demand for energy and nutrients. In the last years, cell cycle regulators have …

Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …

S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …

DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events
or cell death if left unrepaired or repaired inappropriately. Cells use two major pathways for …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

The cell cycle-dependent nucleocytoplasmic transport of proteins is predominantly regulated
by CDK kinase activities; however, it is currently difficult to predict the proteins thus …

Almost two billion years of evolution have generated a vast and amazing variety of
eukaryotic life with approximately 8.7 million extant species. Growth and reproduction of all …

A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …

To explore the mechanisms and evolution of cell-cycle control, we analyzed the position and
conservation of large numbers of phosphorylation sites for the cyclin-dependent kinase …