Cellular immunotherapies represent a promising approach for the treatment of cancer.
Engineered adoptive cell therapies redirect and augment a leukocyte's inherent ability to …

Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Advanced metastatic cancer poses utmost clinical challenges and may present molecular
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …

INTRODUCTION Human skin provides vital protection from water loss and from external
insult through structural adaptations and interplay with the innate and adaptive immune …

Coordinated cell interactions within the esophagus maintain homeostasis, and disruption
can lead to eosinophilic esophagitis (EoE), a chronic inflammatory disease with poorly …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …

The contribution of dendritic cell (DC) antigen cross-presentation to the activation of CD8+ T
lymphocytes for immune defense against tumors, viruses, and intracellular pathogens has …