Ex‐vivo lung perfusion

D Van Raemdonck, A Neyrinck, M Cypel… - Transplant …, 2015 - Wiley Online Library
This review outlines the new and promising technique of ex vivo lung perfusion and its
clinical potential to increase the number of transplantable lungs and to improve the early …

Advanced technologies for the preservation of mammalian biospecimens

H Huang, X He, ML Yarmush - Nature biomedical engineering, 2021 - nature.com
The three classical core technologies for the preservation of live mammalian biospecimens—
slow freezing, vitrification and hypothermic storage—limit the biomedical applications of …

An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome

KC Meyer, G Raghu, GM Verleden, PA Corris, P Aurora… - 2014 - publications.ersnet.org
Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that
is associated with poor survival. The International Society for Heart and Lung …

Normothermic ex vivo lung perfusion in clinical lung transplantation

M Cypel, JC Yeung, M Liu, M Anraku… - New England journal …, 2011 - Mass Medical Soc
Background More than 80% of donor lungs are potentially injured and therefore not
considered suitable for transplantation. With the use of normothermic ex vivo lung perfusion …

[HTML][HTML] Intraoperative extracorporeal membrane oxygenation and the possibility of postoperative prolongation improve survival in bilateral lung transplantation

K Hoetzenecker, S Schwarz, M Muckenhuber… - The Journal of thoracic …, 2018 - Elsevier
Objectives The value of intraoperative extracorporeal membrane oxygenation (ECMO) in
lung transplantation remains controversial. In our department, ECMO has been used …

[HTML][HTML] Bilateral lung transplantation on intraoperative extracorporeal membrane oxygenator: an observational study

K Hoetzenecker, A Benazzo, T Stork, K Sinn… - The Journal of thoracic …, 2020 - Elsevier
Objective Intraoperative extracorporeal membrane oxygenation (ECMO) is usually reserved
to support patients during complex lung transplantation. We hypothesized that a routine …

[HTML][HTML] Experience with the first 50 ex vivo lung perfusions in clinical transplantation

M Cypel, JC Yeung, T Machuca, M Chen… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Normothermic ex vivo lung perfusion is a novel method to evaluate and
improve the function of injured donor lungs. We reviewed our experience with 50 …

Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs

A Wang, RVP Ribeiro, A Ali, E Brambate… - Science Translational …, 2022 - science.org
Donor organ allocation is dependent on ABO matching, restricting the opportunity for some
patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and …

A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization

AT Sage, LL Donahoe, AA Shamandy… - Nature …, 2023 - nature.com
Ex vivo lung perfusion (EVLP) is a data-intensive platform used for the assessment of
isolated lungs outside the body for transplantation; however, the integration of artificial …

[HTML][HTML] Organ donation and utilization in the United States, 1999-2008

AS Klein, EE Messersmith, LE Ratner, R Kochik… - American journal of …, 2010 - Elsevier
Despite the Organ Donation Breakthrough Collaborative's work to engage the transplant
community and the suggested positive impact from these efforts, availability of transplanted …