Progress in toxicogenomics to protect human health
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …
epigenomic modifications, to understand and predict the toxicological effects of …
Current advances in comprehensive omics data mining for oncology and cancer research
E Jeong, S Yoon - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
The availability of a large amount of multiomics data enables data-driven discovery studies
on cancers. High-throughput data on mutations, gene/protein expression, immune scores …
on cancers. High-throughput data on mutations, gene/protein expression, immune scores …
Integrated multi-omics analysis of Alzheimer's disease shows molecular signatures associated with disease progression and potential therapeutic targets
P Kodam, R Sai Swaroop, SS Pradhan… - Scientific reports, 2023 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …
formation of amyloid plaques implicated in neuronal death. Genetics, age, and sex are the …
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma
X Wang, X Wang, J Li, J Liang, X Ren, D Yun… - Cancer Gene …, 2023 - nature.com
The tumor immunosuppressive microenvironment (IME) significantly affects tumor
occurrence, progression, and prognosis, but the underlying molecular mechanisms remain …
occurrence, progression, and prognosis, but the underlying molecular mechanisms remain …
Identification of drug candidates targeting monocyte reprogramming in people living with HIV
R Knoll, L Bonaguro, JC Dos Santos… - Frontiers in …, 2023 - frontiersin.org
Introduction People living with HIV (PLHIV) are characterized by functional reprogramming
of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess …
of innate immune cells even after long-term antiretroviral therapy (ART). In order to assess …
Deep generative modeling of sample-level heterogeneity in single-cell genomics
The field of single-cell genomics is now observing a marked increase in the prevalence of
cohort-level studies that include hundreds of samples and feature complex designs. These …
cohort-level studies that include hundreds of samples and feature complex designs. These …
RummaGEO: automatic mining of human and mouse gene sets from GEO
Summary The Gene Expression Omnibus (GEO) has millions of samples from thousands of
studies. While users of GEO can search the metadata describing studies, there is a need for …
studies. While users of GEO can search the metadata describing studies, there is a need for …
ViCEKb: Vitiligo-linked Chemical Exposome Knowledgebase
Vitiligo is a complex disease wherein the environmental factors, in conjunction with the
underlying genetic predispositions, trigger the autoimmune destruction of melanocytes …
underlying genetic predispositions, trigger the autoimmune destruction of melanocytes …
Central insulin dysregulation in antipsychotic-naïve first-episode psychosis: In silico exploration of gene expression signatures
J Lee, X Xue, E Au, WB McIntyre, R Asgariroozbehani… - Psychiatry …, 2024 - Elsevier
Antipsychotic drug (AP)-naïve first-episode psychosis (FEP) patients display premorbid
cognitive dysfunctions and dysglycemia. Brain insulin resistance may link metabolic and …
cognitive dysfunctions and dysglycemia. Brain insulin resistance may link metabolic and …
Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML
M Marchesini, A Gherli, E Simoncini, LMD Tor… - Nature …, 2024 - nature.com
The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the
most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 …
most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 …