Metformin: update on mechanisms of action and repurposing potential
Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …
Gut microbial carbohydrate metabolism contributes to insulin resistance
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …
diabetes,. Previous metagenomic studies have described the characteristics of gut …
Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota
K Hosomi, M Saito, J Park, H Murakami… - Nature …, 2022 - nature.com
The gut microbiome is an important determinant in various diseases. Here we perform a
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …
Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …
populations have an underlying predisposition to deficient insulin secretion, which has a key …
Dietary fibre modulates the gut microbiota
Dietary fibre has long been established as a nutritionally important, health-promoting food
ingredient. Modern dietary practices have seen a significant reduction in fibre consumption …
ingredient. Modern dietary practices have seen a significant reduction in fibre consumption …
Gut microbiota in human metabolic health and disease
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …
Bioaccumulation of therapeutic drugs by human gut bacteria
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However,
the systematic map** of the interactions between drugs and bacteria has only started …
the systematic map** of the interactions between drugs and bacteria has only started …
Host variables confound gut microbiota studies of human disease
Low concordance between studies that examine the role of microbiota in human diseases is
a pervasive challenge that limits the capacity to identify causal relationships between host …
a pervasive challenge that limits the capacity to identify causal relationships between host …
[HTML][HTML] A faecal microbiota signature with high specificity for pancreatic cancer
Background Recent evidence suggests a role for the microbiome in pancreatic ductal
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and …
adenocarcinoma (PDAC) aetiology and progression. Objective To explore the faecal and …