Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation,
nonalcoholic steatohepatitis (NASH), has a global prevalence of 20–25% and is a major …

Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …

The gut microbiome is an important determinant in various diseases. Here we perform a
cross-sectional study of Japanese adults and identify the Blautia genus, especially B …

Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

Abstract Machine learning is increasingly important in microbiology where it is used for tasks
such as predicting antibiotic resistance and associating human microbiome features with …

Accumulating evidence indicates that gut transit time is a key factor in sha** the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

The gut–liver axis plays a prominent role in the pathogenesis and therapy of metabolic
diseases such as diabetes. The intestinal specific origin of several hormones that guide both …

Dietary fibre has long been established as a nutritionally important, health-promoting food
ingredient. Modern dietary practices have seen a significant reduction in fibre consumption …

Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …