Emerging trends in regenerative medicine: a scientometric analysis in CiteSpace
Introduction: Regenerative medicine involves research in a number of fields and disciplines
such as stem cell research, tissue engineering and biological therapy in general. As …
such as stem cell research, tissue engineering and biological therapy in general. As …
Phenotypic screens as a renewed approach for drug discovery
W Zheng, N Thorne, JC McKew - Drug discovery today, 2013 - Elsevier
Highlights•Phenotypic screening is a renewed approach for lead discovery.•Phenotypic
screen approach may improve the success rate of drug approval.•New drug targets can be …
screen approach may improve the success rate of drug approval.•New drug targets can be …
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers
N Antón-Bolaños, I Faravelli, T Faits, S Andreadis… - Nature, 2024 - nature.com
Interindividual genetic variation affects the susceptibility to and progression of many
diseases,. However, efforts to study how individual human brains differ in normal …
diseases,. However, efforts to study how individual human brains differ in normal …
Precise correction of Duchenne muscular dystrophy exon deletion mutations by base and prime editing
F Chemello, AC Chai, H Li, C Rodriguez-Caycedo… - Science …, 2021 - science.org
Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by the lack of
dystrophin, which maintains muscle membrane integrity. We used an adenine base editor …
dystrophin, which maintains muscle membrane integrity. We used an adenine base editor …
Cell diversity and network dynamics in photosensitive human brain organoids
In vitro models of the develo** brain such as three-dimensional brain organoids offer an
unprecedented opportunity to study aspects of human brain development and disease …
unprecedented opportunity to study aspects of human brain development and disease …
A reference human induced pluripotent stem cell line for large-scale collaborative studies
CB Pantazis, A Yang, E Lara, JA McDonough… - Cell stem cell, 2022 - cell.com
Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …
development and disease, but the considerable phenotypic variation between lines makes it …
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
The findings that amyotrophic lateral sclerosis (ALS) patients almost universally display
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its …
pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its …
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for
modeling neurological diseases. However, iPSC models are fraught with technical …
modeling neurological diseases. However, iPSC models are fraught with technical …
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins
All-optical electrophysiology—spatially resolved simultaneous optical perturbation and
measurement of membrane voltage—would open new vistas in neuroscience research. We …
measurement of membrane voltage—would open new vistas in neuroscience research. We …
[HTML][HTML] Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
nervous system. We show using multielectrode array and patch-clamp recordings that …
nervous system. We show using multielectrode array and patch-clamp recordings that …