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The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments
The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of
schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be …
schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be …
The role of CCL2/CCR2 axis in cerebral ischemia-reperfusion injury and treatment: from animal experiments to clinical trials
H Geng, L Chen, J Tang, Y Chen, L Wang - International journal of …, 2022 - mdpi.com
CC motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …
Precision nomothetic medicine in depression research: a new depression model, and new endophenotype classes and pathway phenotypes, and a digital self
M Maes - Journal of personalized medicine, 2022 - mdpi.com
Machine learning approaches, such as soft independent modeling of class analogy (SIMCA)
and pathway analysis, were introduced in depression research in the 1990s (Maes et al.) to …
and pathway analysis, were introduced in depression research in the 1990s (Maes et al.) to …
CCL-11 or eotaxin-1: an immune marker for ageing and accelerated ageing in neuro-psychiatric disorders
Background: CCL-11 (eotaxin) is a chemokine with an important role in allergic conditions.
Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper …
Recent evidence indicates that CCL-11 plays a role in brain disorders as well. This paper …
The role of G protein-coupled receptors (GPCRs) and calcium signaling in schizophrenia. Focus on GPCRs activated by neurotransmitters and chemokines
T Boczek, J Mackiewicz, M Sobolczyk, J Wawrzyniak… - Cells, 2021 - mdpi.com
Schizophrenia is a common debilitating disease characterized by continuous or relapsing
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …
episodes of psychosis. Although the molecular mechanisms underlying this psychiatric …
Lowered antioxidant defenses and increased oxidative toxicity are hallmarks of deficit schizophrenia: a nomothetic network psychiatry approach
M Maes, S Sirivichayakul, AK Matsumoto… - Molecular …, 2020 - Springer
There is now evidence that schizophrenia and deficit schizophrenia are neuro-immune
conditions and that oxidative stress toxicity (OSTOX) may play a pathophysiological role …
conditions and that oxidative stress toxicity (OSTOX) may play a pathophysiological role …
High mobility group protein 1 and dickkopf-related protein 1 in schizophrenia and treatment-resistant schizophrenia: Associations with interleukin-6, symptom domains …
Background Schizophrenia (SCZ) and treatment-resistant schizophrenia (TRS) are
associated with aberrations in immune-inflammatory pathways. Increased high mobility …
associated with aberrations in immune-inflammatory pathways. Increased high mobility …
Neurocognitive deficits in first-episode and chronic psychotic disorders: A systematic review from 2009 to 2022
N Tschentscher, CFJ Woll, JC Tafelmaier, D Kriesche… - Brain Sciences, 2023 - mdpi.com
Cognitive impairment in patients suffering from schizophrenia spectrum disorders has been
discussed as a strong predictor for multiple disease outcome variables, such as response to …
discussed as a strong predictor for multiple disease outcome variables, such as response to …
Major neurocognitive psychosis: A novel schizophrenia endophenotype class that is based on machine learning and resembles Kraepelin's and Bleuler's conceptions
M Maes - Acta Neuropsychiatrica, 2023 - cambridge.org
The purpose of this study is to describe how to use the precision nomothetic psychiatry
approach to (a) delineate the associations between schizophrenia symptom domains …
approach to (a) delineate the associations between schizophrenia symptom domains …
Increased lipid peroxidation and lowered antioxidant defenses predict methamphetamine induced psychosis
Background: a significant percentage of methamphetamine (MA) dependent patients
develop psychosis. The associations between oxidative pathways and MA-induced …
develop psychosis. The associations between oxidative pathways and MA-induced …