The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

This review focuses on the neuronal and circuit mechanisms involved in the generation of
the theta (θ) rhythm and of its participation in behavior. Data have accumulated indicating …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

In this review we discuss converging evidence from human and rodent research
demonstrating how path integration (PI) is impaired in healthy aging and Alzheimer's …

Path integration is a spatial navigation ability that requires the integration of information
derived from self-motion cues and stable landmarks, when available, to return to a previous …

Whenever we navigate through different contexts, we build a cognitive map: an internal
representation of the territory. Spatial navigation is a complex skill that involves multiple …

Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease
(AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in …

Converging evidence from human and rodent studies suggests that disrupted grid cell
coding in the medial entorhinal cortex (MEC) underlies path integration behavioral deficits …

Progressive cognitive decline in Alzheimer's disease could either be caused by a spreading
molecular pathology or by an initially focal pathology that causes aberrant neuronal activity …

Tauopathies are characterised by the pathological accumulation of misfolded tau. The
emerging view is that toxic tau species drive synaptic dysfunction and potentially tau …