Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently
lacks specific treatment. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon …

Cisplatin (DDP) was reported to improve pathological complete response (pCR) rates in
triple-negative breast cancer (TNBC) patients, however, the molecular mechanism still …

Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment prolongs
the survival of lung cancer patients harbouring activating EGFR mutations. However …

Metformin is a widely used antidiabetic drug for type 2 diabetes that can play a
cardioprotective role through multiple pathways. It is a recognized agonist of AMP-activated …

Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Aim Myocardial infarction (MI) is a severe disease with increased mortality and disability
rates, posing heavy economic burden for society. Exosomes were uncovered to mediate …

Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption
and subsequent release of cellular contents and pro-inflammatory mediators (cytokines) …

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by
gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis …