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[HTML][HTML] Vorinostat (SAHA) and breast cancer: an overview
A Wawruszak, L Borkiewicz, E Okon, W Kukula-Koch… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …
Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment
E Shirbhate, V Singh, V Jahoriya, A Mishra… - European journal of …, 2024 - Elsevier
A significant advancement in the field of epigenetic drug discovery has been evidenced in
recent years. Epigenetic alterations are hereditary, nevertheless reversible variations to …
recent years. Epigenetic alterations are hereditary, nevertheless reversible variations to …
Dual target inhibitors based on EGFR: Promising anticancer agents for the treatment of cancers (2017-)
L Hu, M Fan, S Shi, X Song, F Wang, H He… - European Journal of …, 2022 - Elsevier
The EGFR family play a significant role in cell signal transduction and their overexpression
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …
is implicated in the pathogenesis of numerous human solid cancers. Inhibition of the EGFR …
Multi-targeted HDAC inhibitors as anticancer agents: current status and future prospective
VK Patel, E Shirbhate, P Tiwari, R Kore… - Current Medicinal …, 2023 - benthamdirect.com
Multi-targeted agents can interact with multiple targets sequentially, resulting in synergistic
and more effective therapies for several complicated disorders, including cancer, even with …
and more effective therapies for several complicated disorders, including cancer, even with …
Advances in molecular targeted therapies to increase efficacy of (chemo) radiation therapy
K Viktorsson, T Rieckmann, M Fleischmann… - Strahlentherapie und …, 2023 - Springer
Recent advances in understanding the tumor's biology in line with a constantly growing
number of innovative technologies have prompted characterization of patients' individual …
number of innovative technologies have prompted characterization of patients' individual …
Histone deacetylase inhibitor-based oncolytic virotherapy: A promising strategy for cancer treatment
E Shirbhate, R Veerasamy, SHS Boddu, AK Tiwari… - Drug Discovery …, 2022 - Elsevier
A significant impediment to the treatment of solid and nonsolid cancers is the decline of drug
efficacy and/or occurrence of adverse effects. In recent years, there has been increasing …
efficacy and/or occurrence of adverse effects. In recent years, there has been increasing …
[HTML][HTML] Immunomodulation of HDAC inhibitor entinostat potentiates the anticancer effects of radiation and PD-1 blockade in the murine Lewis lung carcinoma model
Y Kim, K Park, YJ Kim, SW Shin, YJ Kim… - International Journal of …, 2022 - mdpi.com
Although the combination of radiotherapy and immunotherapy has proven to be effective in
lung cancer treatment, it may not be sufficient to fully activate the antitumor immune …
lung cancer treatment, it may not be sufficient to fully activate the antitumor immune …
Valproic acid as a radio-sensitizer in glioma: A systematic review and meta-analysis
JK Sullivan, PP Fahey, KE Agho… - Neuro-Oncology …, 2023 - academic.oup.com
Abstract Background Histone deacetylase inhibitors (HDACi) including valproic acid (VPA)
have the potential to improve radiotherapy (RT) efficacy and reduce treatment adverse …
have the potential to improve radiotherapy (RT) efficacy and reduce treatment adverse …
Selective inhibitors of histone deacetylase 10 (HDAC-10)
E Pojani, D Barlocco - Current Medicinal Chemistry, 2022 - benthamdirect.com
Histone acetylation balance is one epigenetic mechanism controlling gene expression
associated with disease progression. It has been observed that histone deacetylase 10 …
associated with disease progression. It has been observed that histone deacetylase 10 …
[HTML][HTML] Personalized medicine for neuroblastoma: Moving from static genotypes to dynamic simulations of drug response
JZR Han, JF Hastings, M Phimmachanh, D Fey… - Journal of personalized …, 2021 - mdpi.com
High-risk neuroblastoma is an aggressive childhood cancer that is characterized by high
rates of chemoresistance and frequent metastatic relapse. A number of studies have …
rates of chemoresistance and frequent metastatic relapse. A number of studies have …