The effectiveness of quinolone prophylaxis in high-risk hematological pediatric patients is
controversial. A systematic review was performed according to Preferred Reporting Items for …

Background Bacterial infections are common during induction therapy in children and
adolescents with acute leukaemia and may cause infection-related mortality. Aim To …

Leukemia poses significant challenges to its treatment, and understanding its complex
pathogenesis is crucial. This study used metagenomic sequencing to investigate the …

Introduction Most children with leukemia and lymphoma experience febrile neutropenia.
These are treated with empiric antibiotics that include β-lactams and/or vancomycin. These …

There are conflicting recommendations on whether to use or not to use fluoroquinolone
prophylaxis in pediatric oncology patients. An international pediatric clinical practice …

Background The use of fluoroquinolones to prevent infections in neutropenic patients with
cancer or undergoing hematopoietic stem cell transplantation (HSCT) is a controversial …

Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the
effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk …

Bloodstream infections (BSI) are one of the leading causes of morbidity and mortality in
children and young adults receiving chemotherapy for malignancy or undergoing …

The gut microbiome significantly influences the outcomes of pediatric leukemia, particularly
in patients undergoing hematopoietic stem cell transplantation (HSCT). Dysbiosis, caused …

Introduction While clinical practice guidelines (CPGs) for pediatric oncology infection
prophylaxis and management exist, few data describe actual management occurring at …