Cellular compartments and organelles organize biological matter. Most well-known
organelles are separated by a membrane boundary from their surrounding milieu. There are …

Degrons are the elements that are used by E3 ubiquitin ligases to target proteins for
degradation. Most degrons are short linear motifs embedded within the sequences of …

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …

NUP98 fusion oncoproteins (FO) are drivers in pediatric leukemias and many transform
hematopoietic cells. Most NUP98 FOs harbor an intrinsically disordered region from NUP98 …

Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …

Fusion oncoproteins (FOs) resulting from in-frame chromosomal translocations are
associated with many aggressive cancers with poor patient outcomes. Several FOs are now …

Advances in next-generation sequencing have identified thousands of genomic variants that
perturb the normal functions of proteins, further contributing to diverse phenotypic …

The absence of effective delivery vectors and suitable multifunctional plasmids limits cancer
gene therapy development. The star cationic poly (disulfide) s with β‐cyclodextrin cores …

The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …

Osteosarcoma is a type of aggressive malignant bone tumour that frequently metastasizes to
lungs, resulting in poor prognosis. However, the molecular mechanisms of lung metastasis …