Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease

DM Herz, MJ Frank, H Tan, S Groppa - Brain, 2024 - academic.oup.com
Control of actions allows adaptive, goal-directed behaviour. The basal ganglia, including the
subthalamic nucleus, are thought to play a central role in dynamically controlling actions …

Synchronization of complex networks with synapse regulated by energy difference

Y **e, X Li, X Wang, Z Ye, X Hu, Y Hu, Y Jia - Nonlinear Dynamics, 2025 - Springer
Synchronization of neuronal populations in complex networks is essential to understand
information coding and cognitive function, where the energy regulates the firing pattern of …

Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine

A Vishwanath, MJ Bartlett, T Falk, SL Cowen - Brain, 2024 - academic.oup.com
Gamma band and single-unit neural activity in primary motor cortex (M1) are involved in the
control of movement. This activity is disrupted in Parkinson's disease (PD) and levodopa …

Prediction of pathological subthalamic nucleus beta burst occurrence in Parkinson's disease

B Abdi-Sargezeh, S Shirani, A Sharma, A Green… - bioRxiv, 2024 - biorxiv.org
The cortico-basal ganglia network in Parkinson's disease (PD) is characterised by the
emergence of transient episodes of exaggerated beta frequency oscillatory synchrony …

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

TS Binns, RM Köhler, J Vanhoecke, M Chikermane… - bioRxiv, 2024 - biorxiv.org
Deep brain stimulation is a brain circuit intervention that can modulate distinct neural
pathways for the alleviation of neurological symptoms in patients with brain disorders. In …

Network mechanisms in rapid-onset dystonia-parkinsonism

M Moeller, JA Nieweler, V Nikulin, C van Riesen - bioRxiv, 2024 - biorxiv.org
Background: Rapid-onset dystonia-parkinsonism (RDP) is a rare neurological disorder
caused by mutations in the ATP1A3 gene. Symptoms are characterized by a dystonia …

Beta burst characteristics and coupling within the sensorimotor cortical-subthalamic nucleus circuit in Parkinson's disease

P Yao, B Abdi-Sargezeh, A Sharma, T Liu, H Tan… - bioRxiv, 2024 - biorxiv.org
Background: Bursts of exaggerated subthalamic nucleus (STN) beta activity contribute to
clinical impairments in Parkinson's disease (PD). Few studies have explored the …

The Cortical and Subcortical Controls of Postural Instability in People with Parkinson's Disease

J Bath - 2024 - search.proquest.com
Statement of the problem: Gait initiation and turning are fundamental human motor tasks
requiring adept postural control. People with Parkinson's Disease (PD) often exhibit postural …

Deep brain stimulation-entrained gamma oscillations in chronic home recordings in Parkinson's disease

M Olaru, A Hahn, M Shcherbakova, S Little… - Brain Stimulation: Basic … - brainstimjrnl.com
Abstract Background In Parkinson's disease, invasive brain recordings show that
dopaminergic medication can induce narrowband gamma rhythms in the motor cortex and …