[HTML][HTML] Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

CP Lisgaras, HE Scharfman - Neurobiology of disease, 2023 - Elsevier
Interictal spikes (IIS) are a common type of abnormal electrical activity in Alzheimer's
disease (AD) and preclinical models. The brain regions where IIS are largest are not known …

An update of 4‑aminopyride as a useful model of generalized seizures for testing antiseizure drugs: in vitro and in vivo studies

CV Mejía, BH Nuñez‑Ibarra, L Medina‑Ceja - Acta Neurobiologiae …, 2023 - ane.pl
Aminopyridines constitute a drug family with the ability to enhance synaptic transmission. In
particular, 4‑aminopyridine (4‑AP) has been used as a model of generalized seizures. 4‑AP …

Immature Status Epilepticus Alters the Temporal Relationship between Hippocampal Interictal Epileptiform Discharges and High-frequency Oscillations

K Kalogeropoulos, C Psarropoulou - Neuroscience, 2024 - Elsevier
The aim was to investigate the long-term effects of a single episode of immature Status
Epilepticus (SE) on the excitability of the septal and temporal hippocampus in vitro, by …

Timing differences between HFOs and interictal epileptiform discharges generated in vitro by different mechanisms in rat hippocampal slices: A novel approach

K Kalogeropoulos, D Kleidonas… - Epilepsia Open, 2022 - Wiley Online Library
Objective To investigate the effect of generating mechanism on the relationship between
interictal‐like epileptiform discharges (IEDs) and the underlying High Frequency Oscillations …

Region-specific effects of early-life status epilepticus on the adult hippocampal CA3–medial entorhinal cortex circuitry in vitro: focus on interictal spikes and concurrent …

CP Lisgaras, A Mikroulis, C Psarropoulou - Neuroscience, 2021 - Elsevier
Convulsive status epilepticus (SE) in immature life is often associated with lasting
neurobiological changes. We provoked SE by pentylenetetrazole in postnatal day 20 rat …

[PDF][PDF] Interictal spikes in animal models of alzheimer's disease: Dominance of the dentate gyrus and cholinergic control by medial septum

CP Lisgaras, HE Scharfman - Biorxiv, 2023 - researchgate.net
Interictal spikes (IIS) are a common type of abnormal electrical activity in animal models of
Alzheimer's disease (AD) and AD patients. The brain regions where IIS are largest are not …

[HTML][HTML] Prenatal alcohol exposure affects developmental differentiation of interictal discharges in septal and temporal hippocampus

ME Evangelaki, C Psarropoulou - The International Journal of …, 2021 - ijdb.ehu.eus
Prenatal alcohol exposure (PAE) provokes lifelong CNS dysfunction, including an increased
susceptibility to seizure disorders. We investigated hippocampal excitability in vitro in the …

An optimized method for adult zebrafish brain-tissue dissociation that allows access mitochondrial function under healthy and epileptic conditions

L Moro, G Rech, AM Linazzi, TG Dos Santos… - Brain Research, 2021 - Elsevier
Mitochondria play key roles in brain metabolism. Not surprisingly, mitochondria dysfunction
is a ubiquitous cause of neurodegenerative diseases. In turn, acquired forms of epilepsy …