[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …
because many diseases affect the retina and choroid leading to impaired vision or …
The organic anion transporter (OAT) family: a systems biology perspective
The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …
(solute carrier 22) transporter family, has received a great deal of attention because of its …
Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance
This white paper provides updated International Transporter Consortium (ITC)
recommendations on transporters that are important in drug development following the 3rd …
recommendations on transporters that are important in drug development following the 3rd …
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
K Zhou, SW Yee, EL Seiser, N Van Leeuwen… - Nature …, 2016 - nature.com
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its
mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium …
mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium …
[HTML][HTML] Selective drug delivery to the retinal cells: Biological barriers and avenues
E Ramsay, T Lajunen, M Bhattacharya… - Journal of Controlled …, 2023 - Elsevier
Retinal drug delivery is a challenging, but important task, because most retinal diseases are
still without any proper therapy. Drug delivery to the retina is hampered by the anatomical …
still without any proper therapy. Drug delivery to the retina is hampered by the anatomical …
Metabolomic and genome‐wide association studies reveal potential endogenous biomarkers for OATP1B1
SW Yee, MM Giacomini, CH Hsueh… - Clinical …, 2016 - Wiley Online Library
Transporter‐mediated drug‐drug interactions (DDIs) are a major cause of drug toxicities.
Using published genome‐wide association studies (GWAS) of the human metabolome, we …
Using published genome‐wide association studies (GWAS) of the human metabolome, we …
In vitro models of molecular and nano-particle transport across the blood-brain barrier
The blood-brain barrier (BBB) is the tightest endothelial barrier in humans. Characterized by
the presence of tight endothelial junctions and adherens junctions, the primary function of …
the presence of tight endothelial junctions and adherens junctions, the primary function of …
The role of solute carrier transporters in efficient anticancer drug delivery and therapy
E Puris, G Fricker, M Gynther - Pharmaceutics, 2023 - mdpi.com
Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …
key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play …
Blood–brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P‐glycoprotein on a novel verapamil influx carrier
H Chapy, B Saubaméa, N Tournier… - British journal of …, 2016 - Wiley Online Library
Background and Purpose The respective impact and interplay between ABC (P‐
glycoprotein/P‐gp/Abcb1a, BCRP/ABCG2, MRP/ABCC) and SLC transporter functions at the …
glycoprotein/P‐gp/Abcb1a, BCRP/ABCG2, MRP/ABCC) and SLC transporter functions at the …
Atropine in topical formulations for the management of anterior and posterior segment ocular diseases
I Garcia Del Valle… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Atropine is an old-known drug which is gaining increasing attention due to the
myriad of therapeutic effects it may trigger on eye structures. Nevertheless, novel …
myriad of therapeutic effects it may trigger on eye structures. Nevertheless, novel …