The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

H Zhang, JL Liesveld, LM Calvi, BC Lipe, L **ng… - Bone Research, 2023 - nature.com
Prior research establishing that bone interacts in coordination with the bone marrow
microenvironment (BMME) to regulate hematopoietic homeostasis was largely based on …

[HTML][HTML] An overview of multiple myeloma: A monoclonal plasma cell malignancy's diagnosis, management, and treatment modalities

MS Abduh - Saudi Journal of Biological Sciences, 2024 - Elsevier
Multiple Myeloma (MM) is a plasma cell cancer with high mortality and morbidity rates. Its
incidence rate has increased by 143% since 1975. Adipokines, cytokines, chemokines, and …

Epidemiology of invasive pneumococcal infections: manifestations, incidence and case fatality rate correlated to age, gender and risk factors

E Backhaus, S Berg, R Andersson, G Ockborn… - BMC infectious …, 2016 - Springer
Background Incidence, manifestations and case-fatality rate (CFR) of invasive
pneumococcal disease (IPD) vary with age and comorbidities. New vaccines, changing age …

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases

K Hemminki, A Försti, R Houlston… - International journal of …, 2021 - Wiley Online Library
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of
plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 …

Monoclonal gammopathy of undetermined significance

WI Gonsalves, SV Rajkumar - Annals of internal medicine, 2022 - acpjournals.org
Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical
importance to primary care physicians given its high prevalence in the general population …

Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias

MAV Willrich, JA Katzmann - Clinical Chemistry and Laboratory …, 2016 - degruyter.com
Monoclonal immunoglobulins are markers of plasma cell proliferative diseases and have
been described as the first (and perhaps best) serological tumor marker. The unique …

Differential diagnosis of monoclonal gammopathy of undetermined significance

G Merlini, G Palladini - Hematology 2010, the American Society …, 2012 - ashpublications.org
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma
cell disorder occurring in 4.2% of adults> 50 years of age, which can progress into …

Efficient 1-hour technetium-99 m pyrophosphate imaging protocol for the diagnosis of transthyretin cardiac amyloidosis

A Masri, S Bukhari, S Ahmad, R Nieves… - Circulation …, 2020 - ahajournals.org
Background: Technetium-99 m pyrophosphate protocols for transthyretin cardiac
amyloidosis diagnosis have variably used 1-and 3-hour imaging time points. We …

Fibrillary glomerulonephritis: clinicopathologic features and atypical cases from a multi-institutional cohort

NK Andeen, ML Troxell, M Riazy… - Clinical Journal of the …, 2019 - journals.lww.com
Results We retrospectively reviewed kidney biopsies from patients diagnosed with fibrillary
GN or suspected fibrillary GN between 1997 and 2017 (n= 266, 65% female, median age …

Laboratory testing for monoclonal gammopathies: focus on monoclonal gammopathy of undetermined significance and smoldering multiple myeloma

MAV Willrich, DL Murray, RA Kyle - Clinical Biochemistry, 2018 - Elsevier
Monoclonal gammopathies (MG) are defined by increased proliferation of clonal plasma
cells, resulting in a detectable abnormality called monoclonal component or M-protein …