Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and
Bone was published in early 2020. The revisions reflect a consensus among an …

The fifth edition of the World Health Organization (WHO) classification of soft tissue and
bone tumours was published in May 2020. This 'Blue Book', which is also available digitally …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

Abstract Neurofibromatosis type 1 (NF1) is a common genetic disorder that predisposes
affected individuals to tumours. The NF1 gene encodes a RAS GTPase-activating protein …

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-
specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

Mutations or aberrant upregulation of EZH2 occur frequently in human cancers, yet clinical
benefits of EZH2 inhibitor (EZH2i) remain unsatisfactory and limited to certain hematological …

The diagnosis of malignant peripheral nerve sheath tumor is challenging, particularly in the
sporadic setting. Inactivation of the polycomb repressive complex 2 (PRC2), resulting from …