Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …

Isoform 1 of DNA methyltransferase DNMT3A (DNMT3A1) specifically recognizes
nucleosome monoubiquitylated at histone H2A lysine-119 (H2AK119ub1) for establishment …

Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …

The liverwort Marchantia polymorpha has been utilized as a model for biological studies
since the 18th century. In the past few decades, there has been a Renaissance in its …

DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

Polycomb group proteins and the related histone modification H3K27me3 can maintain the
silencing of key developmental regulators and provide cellular memory. However, how such …