Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives
X Mao, J Xu, W Wang, C Liang, J Hua, J Liu, B Zhang… - Molecular cancer, 2021 - Springer
Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …
phenotypic and functional heterogeneity, are the most essential components of the tumor …
Overcoming TGFβ-mediated immune evasion in cancer
Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
development and tissue homeostasis; hence, dysregulation of this pathway can drive …
Targeting TGFβ signal transduction for cancer therapy
S Liu, J Ren, P Ten Dijke - Signal transduction and targeted therapy, 2021 - nature.com
Transforming growth factor-β (TGFβ) family members are structurally and functionally related
cytokines that have diverse effects on the regulation of cell fate during embryonic …
cytokines that have diverse effects on the regulation of cell fate during embryonic …
Influence of the tumor microenvironment on NK cell function in solid tumors
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …
host immune responses against infection and tumor growth. These cells have a powerful …
Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β
Y Lan, D Zhang, C Xu, KW Hance, B Marelli… - Science translational …, 2018 - science.org
Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …
therapies, but not all patients respond to these as single agents. Concurrently targeting …
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach for combating cancers, demonstrating remarkable …
promising immunotherapeutic approach for combating cancers, demonstrating remarkable …
Plasticity of innate lymphoid cell subsets
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …
IL-37 is a fundamental inhibitor of innate immunity
The function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive.
Expression of IL-37 in macrophages or epithelial cells almost completely suppressed …
Expression of IL-37 in macrophages or epithelial cells almost completely suppressed …
The polarization of immune cells in the tumour environment by TGFβ
Transforming growth factor-β (TGFβ) is an immunosuppressive cytokine produced by tumour
cells and immune cells that can polarize many components of the immune system. This …
cells and immune cells that can polarize many components of the immune system. This …
Alteration of the antitumor immune response by cancer-associated fibroblasts
Among cells present in the tumor microenvironment, activated fibroblasts termed cancer-
associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma …
associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma …