Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures
to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer …

Over the past decade, we have made considerable progress in establishing diffuse intrinsic
pontine glioma (DIPG) as a disease entity and develo** preclinical tools to interrogate …

Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug
delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) …

Convection-enhanced delivery (CED) is a promising technique that generates a pressure
gradient at the tip of an infusion catheter to deliver therapeutics directly through the …

Convection-enhanced delivery (CED) is a bulk flow–driven process. Its properties permit
direct, homogeneous, targeted perfusion of CNS regions with putative therapeutics while …

Primary brain tumors have a significant infiltrative capacity as their reappearance after
resection usually occurs within 2cm of the tumor margin. Local delivery method such as …

The authors review the preclinical and clinical results of the ligand-targeted toxin conjugate
Transferrin-CRM107 (Tf-CRM107), for the treatment of malignant gliomas. Tf-CRM107 is a …

Non-invasive drug delivery across the blood–brain barrier (BBB) represents a significant
advancement in treating neurological diseases. The BBB is a tightly packed layer of …

Effective treatment of glioblastoma (GBM) remains a formidable challenge. Survival rates
remain poor despite decades of clinical trials of conventional and novel, biologically …

✓ Convection-enhanced delivery (CED) is the continuous injection under positive pressure
of a fluid containing a therapeutic agent. This technique was proposed and introduced by …