Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …

The Caenorhabditis elegans genome possesses homologs of about two-thirds of all human
disease genes. Based on its physiological aging characteristics and superiority, the use of …

Food protein amyloid fibrils have superior technological, nutritional, sensorial, and physical
properties compared to native monomers, but there is as yet insufficient understanding of …

Phase separation of biomolecules into condensates has emerged as a mechanism for
intracellular organization and affects many intracellular processes, including reaction …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Both acute proteotoxic stresses that unfold proteins and expression of disease-causing
mutant proteins that expose aggregation-prone regions can promote protein aggregation …

Plants produce a diversity of plant secondary metabolites (PSMs), which function as defense
chemicals against herbivores and microorganisms but also as signal compounds. An …

Aging has been associated with a progressive decline of proteostasis, but how this process
affects proteome composition remains largely unexplored. Here, we profiled more than …

Chaperones are central to the proteostasis network (PN) and safeguard the proteome from
misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 …