The timely reconstitution and regain of function of a donor-derived immune system is of
utmost importance for the recovery and long-term survival of patients after allogeneic …

The presentation of exogenous antigens on MHC class I molecules, known as cross-
presentation, is essential for the initiation of CD8+ T cell responses. In vivo, cross …

Immunological dysregulation is the cause of many non-infectious human diseases such as
autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction …

The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced
in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the …

CD4+ T helper cells are a central element of the adaptive immune system. They protect the
organism against a wide range of pathogens and are able to initiate and control many …

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Abstract Naturally arising CD25+ CD4+ regulatory T cells actively maintain immunological
self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

The regulatory T (Treg) cells restrain immune responses through suppressor-function
elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a …