Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

The Picornaviridae represent a large family of small plus-strand RNA viruses that cause a
bewildering array of important human and animal diseases. Morphogenesis is the least …

The multifunctional nucleocapsid (N) protein in SARS-CoV-2 binds the~ 30 kb viral RNA
genome to aid its packaging into the 80–90 nm membrane-enveloped virion. The N protein …

Viral infection triggers the activation of antiviral innate immune responses in mammalian
cells. Viral RNA in the cytoplasm activates signaling pathways that result in the production of …

Cells have evolved highly specialized sentinels that detect viral infection and elicit an
antiviral response. Among these, the stress-sensing protein kinase R, which is activated by …

Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …

Stress granule (SG) formation is generally triggered as a result of stress-induced translation
arrest. The impact of SG formation on virus replication varies among different viruses, and …

RNA granules are structures within cells that impart key regulatory measures on gene
expression. Two general types of RNA granules are conserved from yeast to mammals …

Zika virus (ZIKV), a member of the Flaviviridae family, has recently emerged as an important
human pathogen with increasing economic and health impact worldwide. Because of its …

The Ras-GAP SH3 domain–binding proteins (G3BP) are essential regulators of the
formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced …