In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

The majority of bacteremias do not develop to sepsis: bacteria are cleared from the
bloodstream. Oxygen released from erythrocytes and humoral immunity kill bacteria in the …

Fluoride is widely used as an anticaries agent in drinking water and a variety of other
vehicles. This use has resulted in major health benefits. However, there are still open …

Abstract Hydrogen peroxide (H 2 O 2) is unique among general toxins, because it is stable
in abiotic environments at ambient temperature and neutral pH, yet rapidly kills any type of …

Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to
degrade hydrogen peroxide into water and oxygen. In low concentrations of hydrogen …

The innate host response system is comprised of various mechanisms for orchestrating host
response to microbial infection of the oral cavity. The heterogeneity of the oral cavity and the …

We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine
metabolism. We show here that CymR plays an important role both in stress response and …

Several key properties of catalase such as thermal stability, resistance to protease
degradation, and resistance to ascorbate inhibition were improved, while retaining its …

Hydrogen peroxide (H2O2) is considered a major endogenous source of oxidative stress to
oral bacteria and also is widely used in oral care products. Our study objectives were to …

The respiratory activities of oral streptococci grown in biofilms were found to be markedly
repressed compared with those of cells from aerobic culture, or for Streptococcus mutans GS …