Lipid-based nanocarriers for RNA delivery
H Yi Xue, P Guo, WC Wen… - Current pharmaceutical …, 2015 - ingentaconnect.com
RNA-interference (RNAi) agents such as small-interfering RNA (siRNA) and micro-RNA
(miRNA) have strong potential as therapeutic agents for the treatment of a broad range of …
(miRNA) have strong potential as therapeutic agents for the treatment of a broad range of …
Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine
HY Xue, S Liu, HL Wong - Nanomedicine, 2014 - Taylor & Francis
siRNAs have immense therapeutic potential for the treatment of various gene-related
diseases ranging from cancer, viral infections and neuropathy to autoimmune diseases …
diseases ranging from cancer, viral infections and neuropathy to autoimmune diseases …
Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
Angiopep targeting to the low-density lipoprotein receptor-related protein-1 (LRP1) was
identified to exhibit high transcytosis capacity and parenchymal accumulation. In this study, it …
identified to exhibit high transcytosis capacity and parenchymal accumulation. In this study, it …
Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display
Y Pi, X Zhang, J Shi, J Zhu, W Chen, C Zhang, W Gao… - Biomaterials, 2011 - Elsevier
Gene therapy is a promising method for osteoarthritis and cartilage injury. However,
specifically delivering target genes into chondrocytes is a great challenge because of their …
specifically delivering target genes into chondrocytes is a great challenge because of their …
Recent advances of siRNA delivery by nanoparticles
X Yuan, S Naguib, Z Wu - Expert opinion on drug delivery, 2011 - Taylor & Francis
Introduction: The field of RNA interference technology has been researched extensively in
recent years. However, the development of clinically suitable, safe and effective drug …
recent years. However, the development of clinically suitable, safe and effective drug …
Nanopharmacology in translational hematology and oncology
Nanoparticles have displayed considerable promise for safely delivering therapeutic agents
with miscellaneous therapeutic properties. Current progress in nanotechnology has put …
with miscellaneous therapeutic properties. Current progress in nanotechnology has put …
Oligonucleotide aptamer-mediated precision therapy of hematological malignancies
S Yang, H Li, L Xu, Z Deng, W Han, Y Liu… - … Therapy-Nucleic Acids, 2018 - cell.com
Precision medicine has recently emerged as a promising strategy for cancer therapy
because it not only specifically targets cancer cells but it also does not have adverse effects …
because it not only specifically targets cancer cells but it also does not have adverse effects …
Gellan gum blended PEI nanocomposites as gene delivery agents: evidences from in vitro and in vivo studies
Branched Polyethylenimine, 25kDa (PEI), was blended with gellan gum, an anionic
heteropolysaccharide, for partial neutralization of its excess positive charge to form gellan …
heteropolysaccharide, for partial neutralization of its excess positive charge to form gellan …
Linear polyethylenimine-graft-chitosan copolymers as efficient DNA/siRNA delivery vectors in vitro and in vivo
Chitosan was partially converted to its chlorohydrin derivative by the reaction with
epichlohydrin, which was subsequently reacted with varying amounts of lPEI (2.5 kD) to …
epichlohydrin, which was subsequently reacted with varying amounts of lPEI (2.5 kD) to …
A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
Background Many in vitro studies have demonstrated that silencing of cancerous genes by
siRNAs is a potential therapeutic approach for blocking tumor growth. However, siRNAs are …
siRNAs is a potential therapeutic approach for blocking tumor growth. However, siRNAs are …