Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

While traditional approaches for disease management in the era of modern medicine have
saved countless lives and enhanced patient well‐being, it is clear that there is significant …

Gene therapy represents a promising cancer treatment featuring high efficacy and limited
side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors. Cationic …

Advances in bioinformatics, genomics, proteomics, and metabolomics have facilitated the
development of novel anticancer agents that have decreased side effects and increased …

Gene therapy using nucleic acids has many clinical applications for the treatment of
diseases with a genetic origin as well as for the development of innovative vaccine …

Abstract Boron Neutron Capture Therapy (BNCT) is an emerging binary radiation therapy
that exhibits high precision and lethlity for tumor. Its clinical efficacy has been demonstrated …

Carriers of genetic material are divided into vectors of viral and non-viral origin. Viral carriers
are already successfully used in experimental gene therapies, but despite advantages such …

Recent mechanistic studies have attempted to deepen our understanding of the process by
which liposome-mediated delivery of genetic material occurs. Understanding the …

The first gene therapy clinical trials were initiated more than two decades ago. In the early
days, gene therapy shared the fate of many experimental medicine approaches and was …

Gold nanostructures possess unique characteristics that enable their use as contrast agents,
as therapeutic entities, and as scaffolds to adhere functional molecules, therapeutic cargo …