The metabolism of L-tryptophan (TRP) regulates homeostasis, immunity, and neuronal
function. Altered TRP metabolism has been implicated in the pathophysiology of various …

Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex
which develops into a certain clinical picture. The pathogenesis and disease course vary …

Background Tryptophan (TRP) is an essential amino acid that must be provided in the diet.
The kynurenine pathway (KP) is the main route of TRP catabolism into nicotinamide …

Chronic kynurenine pathway (KP) activation is implicated in Alzheimer's disease (AD)
pathophysiology and results in quinolinic acid–induced excitotoxic stimulation of the N …

A targeted ultrahigh-performance liquid chromatography tandem mass spectrometry with
electrospray ionization (UHPLC-ESI-MS/MS) method has been developed for the …

Background Both serotonergic signalling disruption and systemic inflammation have been
associated with the pathogenesis of Alzheimer's disease (AD). The common denominator …

The increasing prevalence of neurological disorders such as Alzheimer's, Parkinson's, and
multiple sclerosis presents a significant global health challenge. Despite extensive research …

The aryl hydrocarbon receptor (AhR) is a nuclear protein which, upon association with
certain endogenous and exogenous ligands, translocates into the nucleus, binds DNA and …

Female sex and Apolipoprotein E (APOE) ε4 genotype are top non-modifiable risk factors for
Alzheimer's disease (AD). Although female-unique experiences like parity (pregnancy and …

Pharmacological treatment of major depressive disorder (MDD) still relies on the use of
serotonergic drugs, despite their limited efficacy. A few mechanistically new drugs have …