Sex differences and the endocannabinoid system in pain

HL Blanton, RC Barnes, MC McHann, JA Bilbrey… - Pharmacology …, 2021 - Elsevier
Cannabis use has been increasing in recent years, particularly among women, and one of
the most common uses of cannabis for medical purposes is pain relief. Pain conditions and …

Modulation of pain by estrogens

RM Craft - Pain, 2007 - Elsevier
It has become increasingly apparent that women suffer a disproportionate amount of pain
during their lifetime compared to men. Over the past 15 years, a growing number of studies …

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

SM O'mahony, VD Felice, K Nally, HM Savignac… - Neuroscience, 2014 - Elsevier
Disruption of bacterial colonization during the early postnatal period is increasingly being
linked to adverse health outcomes. Indeed, there is a growing appreciation that the gut …

Sex-related hormonal influences on pain and analgesic responses

RB Fillingim, TJ Ness - Neuroscience & Biobehavioral Reviews, 2000 - Elsevier
Considerable evidence indicates sex-related differences in pain responses and in the
effectiveness of various analgesic agents. Specifically, females are at greater risk for …

[HTML][HTML] Gender-related differences in irritable bowel syndrome: potential mechanisms of sex hormones

M Meleine, J Matricon - World Journal of Gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
According to epidemiological studies, twice as many women as men are affected by irritable
bowel syndrome (IBS) in western countries, suggesting a role for sex hormones in IBS …

Gender differences in irritable bowel syndrome

L Chang, MM Heitkemper - Gastroenterology, 2002 - Elsevier
In the United States and other Western cultures, a greater number of women seek health
care services for symptoms of functional pain disorders, including irritable bowel syndrome …

Does pain vary across the menstrual cycle? A review

S Iacovides, I Avidon, FC Baker - European journal of pain, 2015 - Wiley Online Library
Reproductive hormones are implicated in moderating pain. Animal studies support both
pronociceptive and antinociceptive actions of oestradiol and progesterone suggesting that …

Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences

I Mitrovic, M Margeta-Mitrovic, S Bader… - Proceedings of the …, 2003 - National Acad Sciences
The analgesia produced by inhibitory G protein-coupled receptor agonists involves
coordinated postsynaptic inhibition via G protein-coupled inwardly rectifying potassium …

Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome?

MM Heitkemper, L Chang - Gender medicine, 2009 - Elsevier
Background: An increase in gastrointestinal (GI) symptoms, including bowel discomfort,
abdominal pain/discomfort, bloating, and alterations in bowel patterns, has been reported …

A life of pelvic pain

KJ Berkley - Physiology & behavior, 2005 - Elsevier
Pelvic pain associated with menstruation, ie, dysmenorrhea, is a chronic pelvic pain that not
only interferes with a woman's wellbeing for a large part of her life but also often co-occurs …