Background Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our
understanding of cellular heterogeneity. Current analytical workflows are driven by …

E2F4 was initially described as a transcription factor with a key function in the regulation of
cell quiescence. Nevertheless, a number of recent studies have established that E2F4 can …

Background Integrating data from multiple global assays and curated databases is essential
to understand the spatio-temporal interactions within cells. Different experiments measure …

Gene regulatory networks have been long studied in model organisms as a means of
identifying functional relationships among genes or their corresponding products. Despite …

How to combine heterogeneous data sources for reliable prediction of transcriptional
regulation is a challenge. Here we present an easy but powerful method to integrate …

Abstract Public Health Significance. Idiopathic pulmonary fibrosis (IPF) is a devastating lung
disease affecting over 100,000 people every year in the US There is no prevention, cure, or …

Gene regulatory network (GRN) is a model of a network that describes the relationships
among genes in a given condition. The model can be used to enhance the understanding of …

Abstract Systems biology comprises the global, integrated analysis of large-scale data
encoding different levels of biological information with the aim to obtain global insight into …