Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …

Cancer cells reprogram their copper metabolism to adapt to adverse microenvironments,
such as oxidative stress. The copper chelator elesclomol has been reported to have …

Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in
colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic …

Background Gene-set enrichment analysis is a useful technique to help functionally
characterize large gene lists, such as the results of gene expression experiments. This …

Telomerase activity controls telomere length and plays a pivotal role in stem cells, aging,
and cancer. Here, we report a molecular link between Wnt/β-catenin signaling and the …

Purpose This study aims to develop a robust gene expression classifier that can predict
disease relapse in patients with early-stage colorectal cancer (CRC). Patients and Methods …

Lineage map** has identified both proliferative and quiescent intestinal stem cells, but the
molecular circuitry controlling stem cell quiescence is incompletely understood. By lineage …

The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT
phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is …

Abstract Background Dendritic cells (DCs) are a complex group of cells that play a critical
role in vertebrate immunity. Lymph-node resident DCs (LN-DCs) are subdivided into …