Circadian genes as therapeutic targets in pancreatic cancer
M García-Costela, J Escudero-Feliú… - Frontiers in …, 2020 - frontiersin.org
Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early
metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer …
metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer …
Lidocaine represses proliferation and cisplatin resistance in cutaneous squamous cell carcinoma via miR-30c/SIRT1 regulation
T Liu, F Jiang, LY Yu, YY Wu - Bioengineered, 2022 - Taylor & Francis
This study aimed to determine the effects of lidocaine on cell proliferation and cisplatin
resistance in A431 human cutaneous squamous cell carcinoma (cSCC) cells and elucidate …
resistance in A431 human cutaneous squamous cell carcinoma (cSCC) cells and elucidate …
SIRT1 contributes to neuroendocrine differentiation of prostate cancer
L Ruan, L Wang, X Wang, M He, X Yao - Oncotarget, 2017 - pmc.ncbi.nlm.nih.gov
The epigenetic factor SIRT1 can promote prostate cancer progression, but it is unclear
whether SIRT1 contributes to neuroendocrine differentiation. In this study, we showed that …
whether SIRT1 contributes to neuroendocrine differentiation. In this study, we showed that …
[HTML][HTML] Sirtuin 1 stimulates the proliferation and the expression of glycolysis genes in pancreatic neoplastic lesions
Metabolic reprogramming is a feature of neoplasia and tumor growth. Sirtuin 1 (SIRT1) is a
lysine deacetylase of multiple targets including metabolic regulators such as p53. SIRT1 …
lysine deacetylase of multiple targets including metabolic regulators such as p53. SIRT1 …
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer
Oncogenic mutations in the small GTPase Ras contribute to~ 30% of human cancers.
However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to …
However, Ras mutations alone are insufficient for tumorigenesis, therefore it is paramount to …
Molecular mechanism underlying the actions of antioxidant molecules in digestive disorders
J Gagnière, M Bonnet - Gastrointestinal tissue, 2017 - Elsevier
The gastrointestinal (GI) tract is a major site for the generation of prooxidant molecules.
Reactive oxygen/nitrogen species (ROS/RNS) are produced during normal physiological …
Reactive oxygen/nitrogen species (ROS/RNS) are produced during normal physiological …