Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps
remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS …

Emerging evidence indicates a fundamental role for the epigenome in immunity. Here, we
mapped the epigenomic and transcriptional landscape of immunity to influenza vaccination …