Novel insights into double-stranded RNA-mediated immunopathology
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
Mitophagy for cardioprotection
Mitochondrial function is maintained by several strictly coordinated mechanisms, collectively
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …
termed mitochondrial quality control mechanisms, including fusion and fission, degradation …
The Z-nucleic acid sensor ZBP1 in health and disease
J Maelfait, J Rehwinkel - Journal of Experimental Medicine, 2023 - rupress.org
Nucleic acid sensing is a central process in the immune system, with far-reaching roles in
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …
antiviral defense, autoinflammation, and cancer. Z-DNA binding protein 1 (ZBP1) is a sensor …
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
C Zhao, Y Ma, M Zhang, X Gao, W Liang, Y Qin, Y Fu… - Immunity, 2023 - cell.com
Cyclic guanosine monophosphate (GMP)-AMP (cGAMP) synthase (cGAS) is a universal
double-stranded DNA (dsDNA) sensor that recognizes foreign and self-DNA in the …
double-stranded DNA (dsDNA) sensor that recognizes foreign and self-DNA in the …
The multiple roles of interferon regulatory factor family in health and disease
L Wang, Y Zhu, N Zhang, Y **an, Y Tang, J Ye… - … and Targeted Therapy, 2024 - nature.com
Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …
influence the immune system, impacting both physiological and pathological processes …
S100A8/A9hi neutrophils induce mitochondrial dysfunction and PANoptosis in endothelial cells via mitochondrial complex I deficiency during sepsis
Y Wang, Y Shi, Y Shao, X Lu, H Zhang, C Miao - Cell Death & Disease, 2024 - nature.com
Abstract S100a8/a9, largely released by polymorphonuclear neutrophils (PMNs), belongs to
the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory …
the S100 family of calcium-binding proteins and plays a role in a variety of inflammatory …
Mitochondrial DNA-triggered innate immune response: mechanisms and diseases
Various cellular stress conditions trigger mitochondrial DNA (mtDNA) release from
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …
mitochondria into the cytosol. The released mtDNA is sensed by the cGAS-MITA/STING …
[HTML][HTML] DAMPs in immunosenescence and cancer
Damage-associated molecular patterns (DAMPs) are endogenous molecules released by
cells in response to injury or stress, recognized by host pattern recognition receptors that …
cells in response to injury or stress, recognized by host pattern recognition receptors that …
Mitochondrial nucleic acids in innate immunity and beyond
Mitochondria participate in a wide range of cellular processes. One essential function of
mitochondria is to be a platform for antiviral signaling proteins during the innate immune …
mitochondria is to be a platform for antiviral signaling proteins during the innate immune …
DAMPs and DAMP-sensing receptors in inflammation and diseases
M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …
produced in cellular damage or stress, and they can activate the innate immune system …