Targeting the gut microbiota for cancer therapy
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …
Inflammation and pancreatic cancer: focus on metabolism, cytokines, and immunity
Systemic and local chronic inflammation might enhance the risk of pancreatic ductal
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …
adenocarcinoma (PDAC), and PDAC-associated inflammatory infiltrate in the tumor …
Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies
Cancer is a major health burden worldwide, and despite continuous advances in medical
therapies, resistance to standard drugs and adverse effects still represent an important …
therapies, resistance to standard drugs and adverse effects still represent an important …
Microbial imidazole propionate affects responses to metformin through p38γ-dependent inhibitory AMPK phosphorylation
Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual
variations in responses to this drug. Its mechanism of action is not fully understood, but …
variations in responses to this drug. Its mechanism of action is not fully understood, but …
Intratumoral Fusobacterium Nucleatum Levels Predict Therapeutic Response to Neoadjuvant Chemotherapy in Esophageal Squamous Cell Carcinoma
K Yamamura, D Izumi, R Kandimalla, F Sonohara… - Clinical cancer …, 2019 - AACR
Purpose: Emerging evidence indicates that gut microbiome plays a crucial role in the cancer
pathogenesis. Although Fusobacterium nucleatum (F. nucleatum) is associated with poor …
pathogenesis. Although Fusobacterium nucleatum (F. nucleatum) is associated with poor …
Chemotherapy-induced intestinal microbiota dysbiosis impairs mucosal homeostasis by modulating toll-like receptor signaling pathways
L Wei, XS Wen, CJ **an - International journal of molecular sciences, 2021 - mdpi.com
Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–
100% of patients undergoing chemotherapy, can reduce the patients' quality of life, add …
100% of patients undergoing chemotherapy, can reduce the patients' quality of life, add …
Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
L Zhang, L Jiang, L Yu, Q Li, X Tian, J He… - Nature …, 2022 - nature.com
Anti-cancer immunity and response to immune therapy is influenced by the metabolic states
of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic …
of the tumours. Immune checkpoint blockade therapy (ICB) is known to involve metabolic …
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
R Pothuraju, S Rachagani, WM Junker… - Journal of Experimental …, 2018 - Springer
Background Pancreatic cancer (PC) is among foremost causes of cancer related deaths
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …
worldwide due to generic symptoms, lack of effective screening strategies and resistance to …
The intricate relationship between diabetes, obesity and pancreatic cancer
Pancreatic cancer is one of the leading determinants of global cancer mortality, and its
incidence is predicted to increase, to become in 2030 the second most common cause of …
incidence is predicted to increase, to become in 2030 the second most common cause of …
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
Y Wang, G Yang, L You, J Yang, M Feng, J Qiu… - Molecular Cancer, 2019 - Springer
Pancreatic cancer is one of the most lethal malignancies. Recent studies indicated that
development of pancreatic cancer may be intimately connected with the microbiome. In this …
development of pancreatic cancer may be intimately connected with the microbiome. In this …