Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

Glycosaminoglycans (GAGs) are complex carbohydrates that are ubiquitously present on
the cell surface and in the extracellular matrix. Interactions between GAGs and pathogens …

Plasmodium falciparum engineer infected erythrocytes to present the malarial protein,
VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the …

Abstract Background Virus-like particles (VLPs) represent a significant advance in the
development of subunit vaccines, combining high safety and efficacy. Their particulate …

The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …

Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …

Rationale: The availability of therapeutics to treat pregnancy complications is severely
lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium …

Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …

Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …

During placental malaria, Plasmodium falciparum infected erythrocytes sequester in the
placenta, causing health problems for both the mother and fetus. The specific adherence is …