Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

Intestinal fibrosis is considered an inevitable complication of Crohn's disease (CD) that
results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment …

Objectives To assess the effects of Rituximab (RTX) on skin and lung fibrosis in patients with
systemic sclerosis (SSc) belonging to the European Scleroderma Trial and Research …

Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients
with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in …

Background Interstitial lung disease (ILD) frequently complicates systemic autoimmune
disorders resulting in considerable morbidity and mortality. The connective tissue diseases …

Background The treatment of systemic sclerosis (SSc) represents a great clinical challenge
because of the complex disease pathogenesis including vascular, fibrotic, and immune T …

Objectives. To assess the safety and efficacy of long-term treatment with rituximab (RTX) in
patients with systemic sclerosis (SSc). Methods. Eight patients with SSc-associated …

Objectives To assess the long-term efficacy and safety of single and multiple courses of
rituximab therapy in systemic sclerosis (SSc) patients with and without lung disease …

Objective. To assess clinical outcomes including imaging findings on computed tomography
(CT), pulmonary function testing (PFT), and glucocorticoid (GC) use in patients with the …

Introduction B lymphocytes might play a pathogenic role in dermal fibrosis in systemic
sclerosis (SSc). B-cell activating factor (BAFF), a key cytokine for B-cell activation, is …