Nitric oxide signaling in health and disease

JO Lundberg, E Weitzberg - Cell, 2022 - cell.com
The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages

M Rath, I Müller, P Kropf, EI Closs… - Frontiers in …, 2014 - frontiersin.org
Macrophages play a major role in the immune system, both as antimicrobial effector cells
and as immunoregulatory cells, which induce, suppress or modulate adaptive immune …

Antimicrobial strategies centered around reactive oxygen species–bactericidal antibiotics, photodynamic therapy, and beyond

F Vatansever, WCMA de Melo, P Avci… - FEMS microbiology …, 2013 - academic.oup.com
Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial
activity, which accounts for their versatility in mediating host defense against a broad range …

The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

DB Graves - Journal of Physics D: Applied Physics, 2012 - iopscience.iop.org
Reactive oxygen species (ROS) and the closely related reactive nitrogen species (RNS) are
often generated in applications of atmospheric pressure plasmas intended for biomedical …

Fluorescent indicators based on BODIPY

N Boens, V Leen, W Dehaen - Chemical Society Reviews, 2012 - pubs.rsc.org
This critical review covers the advances made using the 4-bora-3a, 4a-diaza-s-indacene
(BODIPY) scaffold as a fluorophore in the design, synthesis and application of fluorescent …

Optically-controlled bacterial metabolite for cancer therapy

DW Zheng, Y Chen, ZH Li, L Xu, CX Li, B Li… - Nature …, 2018 - nature.com
Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural
vehicles for tumor targeting. However, neither current chemical nor genetic approaches …

Impact of albumin on drug delivery—New applications on the horizon

B Elsadek, F Kratz - Journal of Controlled Release, 2012 - Elsevier
Over the past decades, albumin has emerged as a versatile carrier for therapeutic and
diagnostic agents, primarily for diagnosing and treating diabetes, cancer, rheumatoid …

The L-arginine-nitric oxide pathway

S Moncada, A Higgs - New England journal of medicine, 1993 - Mass Medical Soc
The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

JS Beckman, TW Beckman, J Chen… - Proceedings of the …, 1990 - National Acad Sciences
Superoxide dismutase reduces injury in many disease processes, implicating superoxide
anion radical (O2-.) as a toxic species in vivo. A critical target of superoxide may be nitric …

Arginine metabolism: nitric oxide and beyond

G Wu, SM Morris Jr - Biochemical Journal, 1998 - portlandpress.com
Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for
the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline …