Alzheimer's disease and its treatment by different approaches: A review

S Srivastava, R Ahmad, SK Khare - European Journal of Medicinal …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mental ability
development and interrupts neurocognitive function. This neuropathological condition is …

The pharmacological action of kaempferol in central nervous system diseases: A review

J Silva dos Santos, JP Goncalves Cirino… - Frontiers in …, 2021 - frontiersin.org
Kaempferol (KPF) is a flavonoid antioxidant found in fruits and vegetables. Many studies
have described the beneficial effects of dietary KPF in reducing the risk of chronic diseases …

Updates in Alzheimer's disease: from basic research to diagnosis and therapies

E Liu, Y Zhang, JZ Wang - Translational Neurodegeneration, 2024 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

[HTML][HTML] Link between diabetes and Alzheimer's disease due to the shared amyloid aggregation and deposition involving both neurodegenerative changes and …

GD Stanciu, V Bild, DC Ababei, RN Rusu… - Journal of Clinical …, 2020 - mdpi.com
Diabetes and Alzheimer's disease are two highly prevalent diseases among the aging
population and have become major public health concerns in the 21st century, with a …

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery

S Kumari, K Maddeboina, RD Bachu, SHS Boddu… - Drug Discovery …, 2022 - Elsevier
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively
worsens with time. Clinical options are limited and only provide symptomatic relief to AD …

N1-methylation of adenosine (m1A) in ND5 mRNA leads to complex I dysfunction in Alzheimer's disease

M Jörg, JE Plehn, M Kristen, M Lander, L Walz… - Molecular …, 2024 - nature.com
One mechanism of particular interest to regulate mRNA fate post-transcriptionally is mRNA
modification. Especially the extent of m1A mRNA methylation is highly discussed due to …

Amyloid cascade hypothesis for the treatment of alzheimer's disease: progress and challenges

T Wu, D Lin, Y Cheng, S Jiang, MW Riaz… - Aging and …, 2022 - pmc.ncbi.nlm.nih.gov
The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

Pharmacotherapy of Alzheimer's disease: Seeking clarity in a time of uncertainty

N Husna Ibrahim, MF Yahaya, W Mohamed… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is recognized as a major health hazard that mostly affects people
older than 60 years. AD is one of the biggest medical, economic, and social concerns to …

Review of PINK1-Parkin-mediated mitochondrial autophagy in Alzheimer's disease

TY Zhou, RX Ma, J Li, B Zou, H Yang, RY Ma… - European Journal of …, 2023 - Elsevier
Mitochondrial autophagy plays an important role in maintaining the complexity of
mitochondrial functions and removing damaged mitochondria, of which the PINK1-Parkin …

Mitochondrial Dysfunction and Alpha‐Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?

SM Dos Santos, CFR Romeiro… - Oxidative medicine …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by impairments in
the cognitive domains associated with orientation, recording, and memory. This pathology …