Opportunities and challenges in enhancing the bioavailability and bioactivity of dietary flavonoids: A novel delivery system perspective

D Yuan, Y Guo, F Pu, C Yang, X **ao, H Du, J He, S Lu - Food Chemistry, 2024 - Elsevier
Flavonoids have multiple favorable bioactivities including antioxidant, anti-inflammatory, and
antitumor. Currently, flavonoid-containing dietary supplements are widely tested in clinical …

Deep Eutectic Solvents: An Eco‐friendly Design for Drug Engineering

F Oyoun, A Toncheva, LC Henríquez… - …, 2023 - Wiley Online Library
In the spirit of circular economy and sustainable chemistry, the use of environmentally
friendly chemical products in pharmacy has become a hot topic. In recent years, organic …

Fisetin—In search of better bioavailability—From macro to nano modifications: A review

J Szymczak, J Cielecka-Piontek - International Journal of Molecular …, 2023 - mdpi.com
As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They
are in high demand because of their many health benefits. However, their low bioavailability …

Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells

R Kubina, K Krzykawski, A Dziedzic, A Kabała-Dzik - Cells, 2023 - mdpi.com
Despite the relative effectiveness of standard cancer treatment strategies, head and neck
cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While …

A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

S Sip, N Rosiak, A Sip, M Żarowski, K Hojan… - Antioxidants, 2023 - mdpi.com
Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An
amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction …

Drug nanocrystals: Surface engineering and its applications in targeted delivery

P Lhaglham, L Jiramonai, Y Jia, B Huang, Y Huang… - iScience, 2024 - cell.com
Drug nanocrystals have received significant attention in drug development due to their
enhanced dissolution rate and improved water solubility, making them effective in …

Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and …

HM Morsy, MY Zaky, NYS Yassin… - International Journal of …, 2024 - Elsevier
Flavonoids, a type of natural polyphenolic molecule, have garnered significant research
interest due to their ubiquitous nature and diverse biological activities, including antioxidant …

[HTML][HTML] A novel temperature-controlled media milling device to produce drug nanocrystals at the laboratory scale

EJ Catlin, OE Fandiño, L Lopez-Vidal… - International Journal of …, 2024 - Elsevier
Poor aqueous solubility of preexisting and emerging drug molecules is a common issue
faced in the field of pharmaceutics. To address this, particle size reduction techniques …

Quality by design-oriented formulation optimization and characterization of guar gum-pectin based oral colon targeted liquisolid formulation of xanthohumol

S Chatterjee, L Corrie, M Hanmantrao… - Journal of Drug Delivery …, 2023 - Elsevier
In the present study a colon targeted liquisolid powder of xanthohumol was developed using
Central Composite Design (CCD). Xanthohumol is a drug obtained from hops plants that …

Glucose-capped fisetin silver nanoparticles induced cytotoxicity and ferroptosis in breast cancer cells: a molecular perspective

K Subhalakshmi, VP Veeraraghavan… - Inorganic Chemistry …, 2024 - Elsevier
Breast cancer is a prevalent malignancy that poses a significant health threat globally
among the women population. In this study, we sought to investigate the cytotoxic and …